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Participants must answer at least 12 of 15 questions correctly (80%) to earn CE credit.

Note: Exercise 994 is a special edition of the Self-Instruction Exercises and is only available to those members/nonmembers who attended the 2017 Scientific Session in Las Vegas. If you submit exercise 994 but did not attend the Scientific Session, the exercise will not be processed and your payment will be returned.

AGD - Self-Instruction Exercise No. 410 - Basic Science
What every dentist should know about statins

Self-Instruction Exercise No. 410
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Exercise No. 410
Subject Code: 010
Basic Science

The 15 questions for this exercise are based on the article, What every dentist should know about statins on pages 66-69. This exercise was developed by Robert A. Busto, DMD, MBA, FAGD, in association with the General Dentistry Self-Instruction committee.

Reading the article and successfully completing this exercise will enable you to:

  • review cellular pathways pertinent to statins;
  • recognize some of the risks and benefits of statins; and
  • understand new therapeutic roles for statins in medical and dental settings.

Answers for this exercise must be received by August 31, 2018.

  1. Statins were originally derived in 1976 by ________.

    A. synthetic cis-selective allylation of an α-alkoxy N-acyliminium ion
    B. isolation from a Penicillium mold
    C. fermentation of oyster mushrooms
    D. purification from red yeast rice

  2. Statins prevent mevalonate from being formed by blocking ________.

    A. HMG-CoA reductase
    B. mevalonate kinase
    C. squalene monoxygenase
    D. thiolase

  3. Inhibition of mevalonate results in decreases in each of the following except one. Which is the exception?

    A. inflammatory markers
    B. T-cell activation
    C. clotting
    D. platelet production

  4. Lower rates of sepsis have been demonstrated in cardiovascular studies where adjunct statin treatment was administered. Statins have been shown to act against a variety of bacterial pathogens.

    A. Both statements are true.
    B. The first statement is true; the second is false.
    C. The first statement is false; the second is true.
    D. Both statements are false.

  5. New-onset diabetes is observed in ___% of statin users.

    A. 2
    B. 4
    C. 6
    D. 8

  6. What percentage of severe sepsis cases result in death?

    A. 7
    B. 18
    C. 29
    D. 41

  7. Atorvastatin-treated hyperlipidemic patients had significantly lower ________ and ________ measurements than controls.

    A. probing depth; gingival index
    B. bleeding; tooth mobility
    C. plaque; calculus
    D. recession; suppuration

  8. Administration of statins by ________ has been shown to enhance mandibular bone formation with the use of surgically placed membranes.

    A. topical gel
    B. local injection
    C. oral tablets
    D. sublingual absorption

  9. Tan et al demonstrated that administration of simvastatin increased bone formation, promoted osseointegration, and enhanced implant fixation in a _______ model.

    A. rat
    B. pig
    C. chimpanzee
    D. dog

  10. Statins have been shown to interfere with or inhibit all of the following except one. Which is the exception?

    A. p53
    B. Ras
    C. PI3K
    D. BMP-2

  11. Atherosclerosis is caused by the accumulation of ________ and deposition of low-density lipoproteins without adequate removal by high-density lipoproteins.

    A. red blood cells
    B. white blood cells
    C. platelets
    D. bacterial cells

  12. In periodontal patients, statin administration reportedly decreases gingival crevicular fluid levels of all of the following except one. Which is the exception?

    A. tumor necrosis factor α
    B. osteoprotegerin
    C. interleukin 1β
    D. matrix metalloproteinases

  13. Patients treated with high-dose atorvastatin were observed to have a significant decrease in periodontal inflammation, as measured by ________ and C-reactive protein levels, after 12 weeks of treatment.

    A. cone beam computed tomography
    B. full-mouth radiography
    C. magnetic resonance imaging
    D. positron emission tomography

  14. Rhabdomyolysis, acute kidney injury, and mortality risks are increased with the concurrent use of statins and ________ or ________.

    A. amoxicillin; clindamycin
    B. levofloxacin; metronidazole
    C. erythromycin; clarithromycin
    D. cephalexin; sulfamethoxazole/trimethoprim

  15. Myalgia is seen in approximately ___% of statin patients.

    A. 5
    B. 10
    C. 15
    D. 20


Evaluation

Please respond to the statements below, using the following scale:
1 Poor; 2 Below average; 3 Average; 4 Above average; 5 Excellent

Practicality of the content 1 2 3 4 5
Benefit to your clinical practice 1 2 3 4 5
Quality of illustrations 1 2 3 4 5
Clarity of objectives 1 2 3 4 5
Clarity of exercise questions 1 2 3 4 5
Relevance of exercise questions 1 2 3 4 5
 
Did this exercise achieve its objectives? Yes No
Did this article present new information? Yes No
How much time did it take you to complete this exercise? mins


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